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Individuals with thiamine-responsive PDHA1 variants tend to more often have a mild to moderate phenotype, likely depending on disease onset and start and choices of management interventions after diagnosis is established

Germ-free mice display defects in several specific immune cell populations, such as impaired innate lymphocyte function, lack of IgA-producing plasma cells, and, more generally, increased susceptibility to infection (38)

doi: 10.1038/s41580-020-00324-8 186 YeePPWeiYKimS-YLuTChihSYLawsonCet al

Depending to Kowalska et al
