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Aberrant cholesterol metabolism has been noted in several diseases of the eye, including age-related macular degeneration, diabetic retinopathy and other common eye conditions such as cataracts, corneal diseases and dry eye syndrome

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Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency.7,8 Autointoxication occurs in these patients due to the accumulations of acylCoA compounds that disrupt intermediary metabolism

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There is currently no data on co-administration of SOF/VEL and acid suppressing medications in patients with CHC and any inferences on the subject must be drawn from data on ledipasvir in genotype 1