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The inclusion and exclusion criteria were defined in direct accordance with the PICOS framework

Treating a B12 deficiency may boost energy and mood, reduce stress and fatigue, and decrease symptoms of multiple conditions

Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study

Metaxas C, Mathis D, Jeger C et al (2017) Early biomarker response and patient preferences to oral and intramuscular Vitamin B12 substitution in primary care: a randomized parallel-group trial