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To test these hypotheses, we used quantitative PCR assays to monitor the expression of carefully selected genes 14 , HSP70, encoding heat shock protein 70, an indicator of cell stress 15,16 , tumour protein P53 ( P53 ), a central transcriptional factor activated by stressors such as UV and involved in cell cycle arrest, DNA repair and apoptosis 17,18 and KIN17 ( KIN ), a cell cycle control protein up-regulated by UV 19,20 and constructed linear mixed effect models 14,21

Target height (MPH) was calculated from the self-reported parental heights by the method of Tanner: (height of the father + height of the mother + 13)/2 for the males and (height of the father + height of the mother 13)/2 for females and expressed in cm [47]

In healthy animals, B-017 did not impact cardiac function in mice (Supplementary Fig

[DOI] [PubMed] [Google Scholar] 15.Mandal M., Sarkar M., Khan A., Biswas M., Masi A., Rakwal R., Agrawal G.K., Srivastava A., Sarkar A

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