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5mCG is mainly located at intergenic regions, repetitive DNA regions, and silenced genes, directly interfering with the binding of certain transcriptional regulators to their cognate DNA sequences or recruiting repressive methyl-CpG binding domain (MBD) proteins [33, 35]

Notably, urinary metabolomic profiling demonstrated significantly elevated Gly excretion in CD patients compared to HCs, potentially indicating altered AAs metabolism characteristic of the disease (Bertini et al

If the response to 200 mg spironolactone within the first two weeks is not sufficient, furosemide with an initial dose of 20-40 mg/d is added

Papadopoulos C, Orso G, Mancuso G, Herholz M, Gumeni S, Tadepalle N, Jungst C, Tzschichholz A, Schauss A, Honing S, Trifunovic A, Daga A, Rugarli EI (2015) Spastin binds to lipid droplets and affects lipid metabolism