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Moreover, studies have shown that atherosclerosis usually precedes ischemic heart disease (Panizzi et al., 2010), and that atherosclerosis induces myocardial infarction, which leads to a drastic reduction in myocardial contractility, dilation of the left ventricle, and a significant reduction in the hearts pumping capacity, which can easily lead to heart failure (Swirski and Nahrendorf, 2013)

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Trimethylamine-N-Oxide instigates NLRP3 inflammasome activation and endothelial dysfunction