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They are given by subcutaneous injection or intravenous infusion

Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, et al

Amylin acts on (1) appetitive/energy-regulating neurons in the hypothalamus impacting food intake, (2) dopaminergic neurons in the ventral tegmental area impacting reward and motivation, and (3) chemoreceptive neurons in the area postrema/nucleus tractus solitarius [60]

Peptides work through different mechanisms, so combining them is safe and potentially more effective than either alone