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We showed that extra-mitochondrial WT PINK1 inhibit tyrosine hydroxylase (TH) and down regulate DA level in DA neurons, whereas pathogenic PINK1 mutations up-regulate TH activity and DA content in DA neurons

[DOI] [PubMed] [Google Scholar] 145.Steur EN, Ballering LA

After that date, it may still be safe and effective, but there is not enough evidence to support beyond that timeframe

Two studies within the review reported that vitamin D levels can also rise in the luteal phase, although more research needs to be done to fully confirm the fluctuations of vitamin D throughout the cycle
