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10.1016/j.isci.2023.108248
Mammals cannot synthesize carnitine from free lysine, but lysine residues that compose certain proteins undergo post-translational N-methylation through the action of methyltransferases that use S-adenosyl methionine as methyl donor, with formation of 6-N-trimethyllysine in the cytoplasm [159, 160]
However, gabapentin did not affect vinctistine-induced allodynia [51, 52]
This activity was also confirmed in vivo in mice inoculated with B-16 melanoma
