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Glossary DCM Diabetic cardiomyopathy IDF International Diabetes Federation ROS Reactive oxygen species GSH Glutathione GPX4 Glutathione peroxidase 4 AGEs Advanced glycation end products Nrf2 Nuclear factor erythroid 2-related factor 2 ARE Antioxidant response element Tf Transferrin Ft Ferritin Fpn Ferroportin IRPs Iron regulatory proteins DMT1 Divalent Metal Transporter 1 System Xc- Cystine/Glutamate Antiporter System Xc- TGF- Transforming growth factor-beta IR Insulin resistance CH Chronic hyperglycemia ATP Adenosine triphosphate ECM Extracellular matrix SGLT-2 Sodium-glucose cotransporter 2 GLP-1 Glucagon-like peptide-1 DPP-4 Dipeptidyl peptidase-4 ACE Angiotensin-converting enzyme ARB Angiotensin receptor blockers TZDs Thiazolidinediones AMPK Adenosine monophosphate-activated protein kinase RAS Renin-Angiotensin Inhibitors EPA Eicosapentaenoic acid COX-1 and COX-2 Cyclooxygenase 1 and 2 NAC N-Acetylcysteine DFO Deferoxamine DFX Deferasirox DFP Deferiprone DEX Dexrazoxane Fer-1 Ferrostatin-1 GPX4 Inhibitors Glutathione Peroxidase 4 Inhibitors DEX Dexmedetomidine HS Hydrogen Sulfide NaHS Sodium Hydrosulfide NAD(P)H Nicotinamide Adenine Dinucleotide (Phosphate) NQO1 Quinone Oxidoreductase 1 GPT Glutamate Pyruvate Transaminase NOX4 NADPH Oxidase 4 REAP1 Receptor Interacting Protein 1 ACSL4 Acyl-CoA Synthetase Long Chain Family Member 4 SLC3A2 Solute Carrier Family 3 Member 2 SLC7A11 Solute Carrier Family 7 Member 11 PUFA Polyunsaturated Fatty Acids PE-PUFA-OOH Phosphatidylethanolamine Polyunsaturated Fatty Acids SOD1 Superoxide Dismutase 1 Nrf2 Nuclear factor erythroid-2-related factor 2 KEAP1 Kelch-like epichlorohydrin (ECH)-associated protein 1 References 1 QuaiyoomAKumarR

Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

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Differentially expressed genes (DEGs) were identified by the limma package (RMA algorithm) with the criterion of P 1[28]

This research uncovers a new way that obesity affects cancer and suggests that drugs like Retatrutide could be used to improve cancer treatment in obese patients