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what is oral melanotic macule Gray on the palate in a 50-year-old female A flat and oval-shaped melanotic
Description
[PubMed: 9153208] 243
In healthy human skin, melanocytes reside within a specialized basement membrane (BM) niche enriched in laminin-211 and relatively devoid of laminin-332
In contrast to cutaneous melanoma, clear cell sarcomas invariably arise in the deep soft tissue of the distal extremities, and 70% possess a consistent balanced translocation t(12;22)(q13;q12) that is not found in melanoma and is believed to be an early, if not primary, event in tumorigenesis
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People with atypical moles may have a family history of melanoma
