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These signs include fatigue, weakness, constipation, reduced appetite, weight loss, along with numbness and tingling sensations in the extremities

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Included studies were limited to those published in English, with at least 6 months of follow-up, and containing data on standardized height before and at the end of study, data on CKD stage (as assessed by glomerular filtration rate (GFR) or degree of renal impairment), mode of renal replacement therapy, child participants only (aged 018 years) and with at least five GH-treated patients

doi: 10.1038/s41419-021-03718-4 44 DollSFreitasFPShahRAldrovandiMda SilvaMCIngoldIet al

And, according to the World Health Organization (WHO), alcohol is responsible for around 4 percent of all cancer deaths globally