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Estimated polygenic score: (1) Major risk factors: GRN, CHI3L1

Furthermore, the l-isomer of N -acetylcysteine (NAC), which is both a cysteine source and an antioxidant, but not d-NAC, which is only an antioxidant 30 , rescued cancer cell growth in cystine-free conditions (Extended Data Fig

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12 Specifically, NAC is thought to affect thioredoxin expression, which regulates DNA binding of NF-kB and glutaredoxin expression that is responsible for detecting changes in the redox state of GSH