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This contrasts with more recent studies of Huang et al

Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration

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Furthermore, the adipokine leptin, which signals adipose tissue mass and energy balance to the brain, also inhibits GH secretion [15, 51] and contributes to IGF-1 regulation [16] and could therefore account for the changes in the GH-IGF axis induced by surgical weight loss

The progression of CHIP-associated atherosclerosis is mediated by the signaling of IL-6 and activation of the inflammasome