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Adiponectin expression and levels in circulation are upregulated by rosiglitazone.[22] TREATMENT OF ACANTHOSIS NIGRICANS Therapeutic approach involves treatment of underlying disease or tumor, cessation/avoidance of the inciting agent in drug-induced AN, use of topical/oral agents and cosmetic surgery.[12] Weight loss and exercise have shown to increase insulin sensitivity and reduce insulin levels causing improvement in obesity associated AN.[23] Correction of hyperinsulinemia reduces hyperkeratotic lesions

In a multiple dose study in a limited number of patients receiving 36 courses of pentostatin at a dosage of 4 mg/sq m iv, distribution half-life and terminal elimination half-life reportedly averaged 9.6 min (range: 3.1-48.5 min) and 4.9 hr, respectively

doi: 10.1016/j.cell.2012.02.017