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Iscan et al

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doi: 10.1093/jrr/rrw105 167 ArpaDParisiEGhigiGCortesiALongobardiPCenniPet al

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Due to its prominence, the nonclinical safety profile of MGL-3623 was evaluated in a 3-month mouse toxicology study, genetic toxicology studies (Ames test, in vitro micronucleus assay in TK6 human lymphoblast cells, and in vivo rat micronucleus assay), an embryo-fetal development (EFD) study in rats, and a 6-month carcinogenicity study in transgenic mice, alongside the parent drug

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Youngblood H, Robinson R, Sharma A, Sharma S (2019) Proteomic biomarkers of retinal inflammation in diabetic retinopathy

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Tumor ethionine metabolic activity is associated with the degree of T cell dysfunction in tumor-associated liver tissues.T cell exhaustion in HCC patients is strongly linked to S-adenosylmethionine (SAM)/5-methylthioadenosine (MTA) levels in the TME [119]

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