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further reported that poliumoside counteracts HGHF-induced bone degradation and ferroptosis by activating the NRF2/GPX4 signaling pathway, suggesting its potential as a novel therapeutic approach for T2DM-associated osteoporosis [176]

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The persistently replicating WT strain provoked higher CD38 expression on the circulating E7 4957 specific CD8 + T cells in the spleen, which indicates that enduring antigenic triggering elevated CD38 expression (Supplemental Figure 5F)

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) (Figure 1) (Imlay, 2013)