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Paclitaxel, a diterpenoid isolated from the bark of Taxus brevifolia, stabilizes microtubules, causes mitotic arrest, and is an FDAapproved firstline chemotherapeutic for multiple breast cancer subtypes (cited [68, 112, 113])

Oxidative stress due to these free radicals containing unpaired electrons can damage cells and the DNA leading to several diseases and even cancers, dementia, Alzheimers disease, Parkinsons disease and coronary heart disease

Nat Rev Microbiol 15:385396 Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-keap1 pathway promotes cell proliferation and diminishes ferroptosis

Lee EG, Kim Y, Hwang YI, Yoo KH, Lee SE, Jung KY, Lee D, Park YB, Rhee CK

Numerous investigations show HIF-1 considerably boosts the healing of injuries via fostering the growth of endothelial cells, keratinocytes, and fibroblasts [8587]