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In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 12% of the total weight of the formulation

CCl 4 induces liver injury through its metabolism by cytochrome P450 enzymes, which generates trichloromethyl free radicals, causing severe hepatocyte damage through lipid peroxidation and cellular dysfunction

10.1016/j.intimp.2009.06.001 Int Immunopharmacol

tb infection and reducing the potential of severe outcomes in diabetic individuals (Figure 11)

Advanced / Extended Approach Note: Advanced dosing (beyond 300 mcg) is based on anecdotal experience