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Description
In cells exposed to hypoxia or ischemia, hypoxia-inducible factor-1 (HIF-1) is upregulated and acts as a key regulator of more than 70 genes, including TNF- , IL-1 , IL-6 , and IL-12 , promoting their expression to potentially harmful levels [15]
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In these cells, increased GPx-1 activity was correlated with decreased ROS accumulation, illustrating a functional effect for increased GPx-1 activity
B.MandalA
2019;10 doi: 10.3389/fpsyt.2019.00034
