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As part of a balanced diet

Novel insights into autoimmune liver diseases provided by genome-wide association studies

Oral dosing studies have used comparable per-kilogram doses with demonstrable efficacy

Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)

This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction