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Description
Mechanistically, CNIs inhibit calcineurin, preventing the dephosphorylation and nuclear translocation of NFATa critical step in cytokine transcription

He called that process cytoprotection

Chen JY, Tran C, Hwang L, Deng G, Jung ME, Faull KF, et al

10.1016/j.biopha.2023.116112 56 YangQ.WangC.JinY.MaX.XieT.WangJ.et al (2019)

This has been explained (155) by the hypothesis that so many biochemical pathways contribute to and result from oxidative stress that blocking one is relatively ineffectual (108, 177)
