n a c or l glutathione for cancer treatment Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cells 🥇 NAC vs Glutathione: Comparing

Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status

Many arginase inhibitors with high affinity have been developed over the past several decades, such as N-hydroxy-L-arginine [NOHA, K i = 3.6 M for human ARG1 (Di Costanzo et al., 2010), 1.6 M for human ARG2 (Colleluori and Ash, 2001)], N-hydroxy-nor-L-arginine [nor-NOHA, K d = 0.47 M for human ARG1 (Di Costanzo et al., 2010), 51 nM for human ARG2 (Colleluori and Ash, 2001)] and boronic acid derivatives like 2(S)-amino-6-hexanoic acid (ABH) [IC 50 values of derivatives range 171,470 nM for human ARG1, 302,150 nM for human ARG2 (Collet et al., 2000

There were several limitations of our work, the main one being that this was an in vitro study using human cell lines in 2D cell cultures

Hooda, Z, Olivera, JA, Rodriguez, E, Ries, S, Jindani, R, Azap, L, Eisenberg, M, Clarke, C, Bostock, I, Alimi, Y, Raz, DJ, Antonoff, MB

GPx7 occurs in the lumen of the endoplasmic reticulum