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The regulation of system X c /GSH/GPX4 axis in ferroptosis As the main antioxidant system against ferroptosis, the role of System X c /GSH/GPX4 axis is crucial in the treatment of various types of drug-resistant solid tumors, so an in-depth understanding of the regulatory mechanism of each node on this axis is of great significance for developing effective strategies for System X c /GSH/GPX4 axis targeted treatment of drug-resistant solid tumors (Figure 1)

Huang WJ, Lu XL, Li JT, Zhang JM

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Compared to the placebo lotion, a ten-week application of 2% oxidized glutathione lotion (GSSG) significantly decreased pigmentation and wrinkling and improved skin moisture and smoothness in the participating women

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