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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity

Melissa Maia Bittencourt has no conflict of interest

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mean increases in resting heart rate of 1 to 4 beats per minute (bpm) were seen with routine clinical monitoring in semaglutide-treated patients vs
