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Treatment of HT patients with selenium yeast tablets for 6 months significantly increased the level of Se, GPx3, and selenoprotein P1 (74)

biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

Bocci F, Tripathi SC, Vilchez Mercedes SA, George JT, Casabar JP, Wong PK, et al

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