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In these systems, nicotinamide adenine dinucleotide phosphate (NADPH) acts as a source of reducing equivalents through two flavoenzymes oxidoreductases: glutathione (GSH) reductase (GR, EC 1.8.1.7) and thioredoxin (Trx) reductase (TR, EC 1.8.1.9) 23

In the matrix, multiple enzymes work together to degrade misfolded, damaged, and oxidized proteins, as well as to turnover some metabolic enzymes, forming the CLPXP complex and Lon protease homolog (LONP)

It helps the body remove harmful substances

This extended trial period (versus typical 30-60 day windows) acknowledges that tissue repair processes are gradual and that fair assessment requires adequate time

doi: 10.1056/NEJMoa0802987 104 Ismail-BeigiFCravenTBanerjiMABasileJCallesJCohenRMet al