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By disrupting disulfide bonds in mucin, it provides potent mucolytic action in COPD, cystic fibrosis, and bronchiectasis, showing synergistic effects with short-acting antimuscarinics (13)

To measure GSSG specifically, researchers first derivatize free GSH using 2-vinylpyridine (2-VP) or N-ethylmaleimide (NEM)

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Napier RJ, Rafi W, Cheruvu M, Powell KR, Zaunbrecher MA, Bornmann W, Salgame P, Shinnick TM, Kalman D