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Moving on to the clinical evidence, folate supplementation (0.55 mg daily) effectiveness in containing HHcy emerged from some meta-analyses evaluating its efficacy both with and without vitamin B6 (mean 16.5 mg daily) and B12 (mean 0.5 mg daily) supplementation

33,34,37 Numerous laxatives are available OTC, but they should be used sparingly
DOI: PMid:25049781

Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)
10.1021/acsami.8b16853 ACS Appl
