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This reduces the ability of the mitochondria to produce the energy molecule ATP, resulting in increased fatigue [55, 56]

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The next generation of microalgal mass culture will be built on the foundation of extensive application of big data analysis and active intervention, which will allow not only the optimal process conditions to be determined for maximal production of microalgal biomass and bioproducts [49, 62], but also tailored contamination control strategies to be formulated to guarantee the quality of the products [22, 71]

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Tumors often display regional heterogeneity in oxygen availability, and this can significantly influence intermediary metabolism independently of tumor genetics