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Sustained glial activation drives neuroinflammation in a vicious cycle via reactive oxygen species (ROS), cytokines, and chemokines (Thakur et al., 2023)
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For instance, LAS17, one of the most effective known inhibitors, has an IC 50 of 500 nM and works by covalently binding to tyrosine residues on GSTP1 (Louie et al
The cloned DNAs were then sequenced
