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Taking a dose of more than 4,000 international units of vitamin D per day for several years may lead to the serum 25(OH)D concentration being in the range of 50 to 150 ng/ml (125 to 375 nmol/L), which may have potential chronic toxicity (172)

As the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, GCH1 converts GTP to BH4, a potent lipid antioxidant capable of directly scavenging lipid peroxides (Kraft et al., 2020

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doi: 10.1080/15412555.2018.1535581

87 Therefore, they control the influx and efflux of chemotherapeutic drugs, modulating the intracellular drug concentration and therefore, determining the therapeutic efficacy and the success or failure of patient treatment