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Nolan (Stanford Univ., Stanford, CA) and transfected with vector containing ABCC1 using polyethyleneimine (PEI) (Boussif et al

Key challenges that remain include gaining a fundamental understanding of ( a ) the molecular mechanisms that drive these diverse phenotypes, ( b ) why chronic disease states ultimately drive low l-serine levels, ( c ) how these findings can be therapeutically exploited, and ( d ) how we can potentially diagnose patients susceptible to l-serine-associated pathologies

S.ChengT.et al (2021)

doi: 10.1016/j.biochi.2021.09.007 37 GuanCXuWHongWZhouMLinFFuLet al

Abbreviations SCI: Spinal cord injury GlyNAC: Glycine and N-acetylcysteine OS: Oxidative stress ROS: Reactive oxygen species GSH: Glutathione SD: SpragueDawley BBB: BassoBeattieBresnahan SOD: Superoxide dismutase MDA: Malondialdehyde T-AOC: Total antioxidant capacity PGC-1: Peroxisome proliferator-activated receptor-gamma coactivator-1alpha RNS: Reactive nitrogen species Atrogin-1: Human dystrophin MuRF1: Muscle-specific RING finger protein 1 References Anwar, M.A., T.S