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Similarly, the FDA-approved drug Ponatinib is a potent small-molecule PD-L1 inhibitor that binds strongly to PD-L1 and, in vivo , delays tumor growth more effectively than an anti-PD-L1 antibody, while enhancing T-Cell activity, offering a promising alternative to antibody-based therapy (73)

It is characterized by continued damage and progressive loss of RGCs and the retinal nerve fiber layer, as well as alterations of the optic disc and optic nerve head, eventually leading to progressive and irreversible constriction and loss of the visual field (Quigley and Broman, 2006

Conclusion In summary, OS, HA, IR, and ovulation disorders are closely related in PCOS patients

It has been observed that BMAL1 may upregulate the expression of VEGF and Angiopoietin 2 (ANG2) via the HIF-1 pathway