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The future of metabolic therapy likely lies not in single interventions but in carefully orchestrated multi-pathway approaches that address the complex, interconnected systems regulating appetite, metabolism, and body composition

For preliminary studies or dose-finding experiments, starting at 7.5mg/kg provides a mid-range target that avoids both under-dosing (which produces false negatives) and excessive dosing (which increases off-target inflammation without improving efficacy).

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L., & Varacallo, M