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Proton Magnetic Resonance Spectroscopy (1H-MRS) has enabled the precise in vivo measurement of intracortical GSH

Among the most important are the degeneration of dopaminergic neurons and the loss of the substantia nigra, combined with the intracellular aggregation of -synuclein, which forms Lewy bodies and neurites [7]

One important ASD-related feature is the loss of Purkinje cell integrity within the cerebellum [115]

These cytokines can act on second messengers such as prostaglandins, activate microglia (the immune cells in the brain), and impact various pathways, including the glutamatergic pathway and the tryptophan and kynurenine system (Figure 2) [121,122,123]

Differences in treatment response may be indicative of differences in etiologies and mechanisms, like neuroinflammation, changes in the neuroendocrine system, or alterations in the gut microbiome (Mousten et al., 2022)