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[9] [10] Argyria occurs in people who ingest or inhale silver in large quantities over a long period (several months to many years)

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Microbiol Mol Biol Rev 81:e00048e00016

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During instances of microbial infection and cellular damage, the NLRP3 inflammasomea vital component of the innate immune systemmaintains regulation over caspase-1 activation and the secretion of pro-inflammatory cytokines such as IL-1/IL-18