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Major adipokines and inflammatory cytokines including IL-6, leptin, adiponectin, IL-1, CXCL1, CXCL2, vascular cell adhesion molecule 1 (VCAM-1), TNF-, and VEGF all serve local and systemic roles in maintaining physiological homeostasis but can also be hijacked by cancer cells to influence tumor survival (81)

In a prospective study conducted in Italy, the sensitivity and specificity of the ANT for diagnosing CHE were 78% and 63%, respectively, when the cut-off was less than 15, and the ANT was a significant predictor for the development of OHE [307]

doi: 10.1113/JP270651

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L-carnitine plays an important role in the translocation of acetyl moieties from the mitochondria to the cytoplasm for acetylcholine synthesis in neurones. Inazu, M and Matsumiya, T, [Physiological functions of carnitine and carnitine transporters in the central nervous system]. in Nihon Shinkew Seishen Yakurigaku Zasshi , Volume 28, Issue 3, June 2008, pp 113 - 120