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Marked thrombosis, arterial and venous, peripherally and centrally, occur as prominent stasis and vessel failure progress (i.e., congested inferior caval vein and superior mesenteric vein, failed azygos vein unable to serve as a rescuing pathway with direct delivery to the superior caval vein [14,15,16,17,18,19,20,21,22,23])

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The third and fourth groups consisted of APP/PS1 mice intranasally administered either Semax (the Semax group) or its derivative (the Heptapeptide group) at a dose of 50 g per kg, starting from the age of 6 months

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