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IL-17 produced by Th17 cells plays a critical role in recruiting inflammatory cells to the injury site (116)

Moreover, HGF is currently under investigation for its potential role in repairing acute spinal cord injuries through ongoing clinical trials (NCT02193334 and NCT04475224)

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Finally, while the mechanical utilization of contractile force produced by myofilaments requires that they should be efficiently connected to tendon fibers, one of the principal obstacles to the use of cytokines and growth factors in tissue engineering provides delivery vehicles that would localize the factor to the repair site for the relevant period of time and appropriate concentration [98]
