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Furthermore, the bloodbrain barrier (BBB) significantly limits the bioavailability of these drugs, as it prevents effective doses from reaching the brain
iv) Hepatocellular carcinoma
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[PubMed 3747094] 1020
The more direct published evidence currently available concerns VEGFR2 expression, VEGFR2-Akt-eNOS signaling, and Src-Cav-1-eNOS pathway activation rather than the complete transcriptional-to-secretory VEGF sequence
