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Exhausted T cells show a reduced capacity to perform metabolic processes such as aerobic glycolysis and oxidative phosphorylation (OXPHOS), both due to external influences and intrinsic signals, such as PD-1 expression (136)

57% had stable or improved EDSS scores (change 0.5 or fewer points)

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Each tablet adds 300mg of alpha lipoic acid, an antioxidant that is both water- and fat-soluble, and 200mg of vitamin C at 333% NRV: vitamin C contributes to the protection of cells from oxidative stress and to the reduction of tiredness and fatigue, and it helps recycle other antioxidants back to their active state

These improvements have clinical significance in both daily life and long-term outcomes