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This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation

Cell 130 , 10951107 (2007)

This is often when more noticeable changes may begin to appear, including: Firmer-looking skin More even-looking texture Continued improvement in the appearance of fine lines Ongoing support for skin renewal A clinical study summarized in a review reported visible skin improvements over about 12 weeks , including better skin density, thickness, and wrinkle appearance

doi: 10.1016/j.freeradbiomed.2021.01.055