paraxanthine elevates catalase glutathione Frontiers paraxanthine increases catalase glutathione Paraxanthine:

Notably, the pool of bidirectionally mobile mitochondria is reduced, impairing both anterograde transport of healthy organelles to distant regions and retrograde movement of damaged mitochondria back to the soma for degradation (Figure 4)

Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia

doi: 10.1016/j.freeradbiomed.2011.04.013

The phenomenon of lactylation represents a burgeoning field, indicating a more advanced role of lactate in metabolic pathways associated with disease

Accordingly, the incidence of CIPN approaches nearly 100% for some agents at higher doses (Seretny et al., 2014), although differences in the definition, evaluation and reporting of peripheral neuronal deficits can lead to large variability in the reported occurrence