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298 Consequently, the primary goal of second-generation mTOR inhibitors is to simultaneously target both the mTORC1 and mTORC2 signaling pathways, as well as their feedback loops, which were not addressed by first-generation inhibitors

10.1016/j.crphar.2022.100083
The pBOO group exhibited glomerular deformation and atrophy, accompanied by tubular injury and marked glomerulosclerosis (Figure 6C)
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