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Two studies directly tested this hypothesis with one negative trial showing no vasodilation (Lauer et al ., 2001) and a second positive study showing significant forearm circulation vasodilation at both pharmacological and slightly supraphysiological concentrations (Cosby et al ., 2003)
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10.1002/jcb.23242 71 KongM.XieK.LvM.LiJ.YaoJ.YanK.et al (2021)
However, hydra-zine bonds can undergo hydrolysis in plasma causing the unintended release of drug molecules leading to systemic toxicity 116
