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Although there are limited reports regarding the association between NNMT and hypertension, our research has identified a significant association between a SNP in the NNMT gene (rs1941404) and hypertension within the Chinese Han population ( While direct evidence linking NNMT activity to hypertension is currently lacking, numerous studies have established a strong association between NNMT activity and various metabolic disorders, including cardiovascular diseases (Williams et al., 2012)

Mutations in the methionine synthase (MTR) gene are also associated with inherited hyperhomocysteinemia

PMID: 41901308

In vertebrates, at least three isozymes exist: the M isozyme (predominant in muscle and brain) and the L isozyme (predominant in liver) are the best characterized