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Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26

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Apart from SOD, CAT and GPX, which are primary antioxidant enzymes found in mammalian cells, there are also enzymes which represent second phase of antioxidant defence in skeletal muscle cells: -glutamylcysteine synthetase (GCS) and heme oxygenase-1 (HO-1)

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Gautam CS, Mahajan SS, Sharma J, Singh H, Singh J