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LC-MS for Metabolite Determination According to our targeted metabolomic experiment, potential metabolite markers were quantitated by comparing the areas of the peaks corresponding to the unlabelled compounds to the areas of the peaks for the external standards (method validation is shown in Supplementary Method II, Supplementary Tables S4, S5, and Supplementary Figure S2) ( Pathway Enrichment Analysis of the HPL Treatment We performed an integrated metabolic pathway analysis of results obtained from combined metabolomics and proteomics datasets conducted to explore the effect of HPL

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Journal of Nutrition, 132(4), 636-42

There is significant increase in the PP2A levels in the hippocampus of rats treated with donepezil (1.055 0.107, p = 0.0128), FD 50 mg/kg (1.228 0.120, p = 0.0004), FD 100 mg/kg (1.138 0.061, p = 0.0024) and FD 200 mg/kg (1.260 0.051, p = 0.0002) compared to the AD rats induced with D-gal and AlCl 3 (0.647 0.040)