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Melanin accumulation and increased hemoglobin cause periorbital hyperpigmentation

[DOI] [PMC free article] [PubMed] [Google Scholar] Taylor T

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In thyrocytes, phosphorylated STAT3 dimers bind to specific DNA sequences called STAT3 response elements within gene promoters, but paradoxically, instead of activating transcription as in many cell types, STAT3 in thyrocytes recruits transcriptional co-repressors, including histone deacetylases HDAC1 and HDAC3, along with nuclear receptor co-repressor (NCoR), to the TPO gene promoter region